Spring Science

Kelly Reynolds has been my right hand and trusted partner in crime over the past few years at Spring Science. Together, we tackled countless startup challenges. She'd be an asset on an ops team, big or small. While my current commitments don't quite allow me to take on an additional startup, I'll offer pro bono advisory hours to support Kelly and her next team. She’s been a rockstar at Spring, and I can’t wait to see where she lands!

We have news to share, and we wish this weren't it. This has been an incredibly hard decision to make, and does not reflect the impact or effort of our team, or the belief of our customers. Our tools are loved by scientists. But, we do not make enough money to continue running the company. Read more about Spring and our closing below.

Rachel Jacobson and our amazing team just published this paper, where we utilized the technology that became the Spring Engine to carryout cell biology at scale. Read the article at the link below - we'll be sharing more shortly!

❗❗❗ Beware of 'AI-washed' products in drug discovery and data analysis!❗❗❗ True innovation isn't about slapping an AI label on old tech. The Spring Engine represents genuine AI advancement, accelerating drug discovery like never before. We'll be digging deeper into this in the coming weeks, so stay tuned! #AI #drugdiscovery #phenotypicprofiling

At Spring Discovery, we're not just using AI – we're redefining it for drug discovery. Our cutting-edge embeddings technology is years ahead of the competition. Discover how we're revolutionizing image analysis: https://xmrrwallet.com/cmx.pbuff.ly/4dLZ6jQ #AIInnovation #DrugDiscovery

🎃 Not all cells go quietly… ☠️ Some die with a bang, others with a whimper, and Spring’s AI tools capture every haunting detail. This Halloween, we’re diving into the eerie world of cell death — from the chaos of necrosis to the fiery cascade of pyroptosis to the precision of apoptosis, each mechanism leaves a unique signature lurking in the shadows. Spring’s AI brings these pathways to light, helping scientists reveal the mysteries of cell fate — no magic required! 🔮🕸️ Happy Halloween, and may your assays be as spooky as they are illuminating! 🧪👻 #HalloweenScience #CellDeath #TechBio #SpringScience #HauntedLabs

👻 Double, double, toil and trouble… 👻 🧪 This Halloween, let’s unmask the ghostly repeat offenders lurking in drug screens. Just like the undead, some compounds keep reappearing as “hits” — but they’re not what they seem! (we're talking about you, colchicine!) 💀 These “phantom hits” can haunt the drug discovery process, leading teams down dead-end paths and wasting resources. Time to exorcise these apparitions with smarter screening techniques! #HalloweenScience #DrugDiscovery #AIinBiotech #NoMoreGhostHits

Exciting developments in live cell imaging are transforming how we observe cellular processes in real-time. A recent preprint introduces Live Cell Painting (LCP), a novel technique using Acridine Orange to visualize multiple cellular structures simultaneously without fixing cells. At Spring Science, we're pushing similar boundaries with our live cell imaging platform. By combining brightfield and fluorescence microscopy (using live cell dyes ChromaLive by our friends at Saguaro Biosciences), researchers can now capture intricate cellular dynamics without disrupting normal function. LCP demonstrates the power of non-invasive methods, revealing subtle changes in vesicle distribution and nuclear morphology in response to various compounds. Similarly, our experimental approaches allow for extended observation of living cells, providing rich phenotypic profiles that can uncover new insights into drug responses and disease mechanisms. The preprint highlights LCP's ability to detect cellular changes at lower concentrations than traditional assays. This aligns with our mission to give scientists more sensitive tools for probing cellular behavior. Our platform's integration of advanced image analysis further empowers researchers to extract meaningful data from complex cellular behavior and morphology. As we continue to refine live cell imaging techniques, the potential for accelerating drug discovery and deepening our understanding of cellular biology has never been greater. What cellular mysteries are you hoping to unravel with these advancing technologies? https://xmrrwallet.com/cmx.pbuff.ly/4e0LOzU #LiveCellImaging #CellBiology #DrugDiscovery

🚀 Unlock the Full Potential of Your Cell Painting Data with Spring Science! 🚀 Stop worrying about building complex, custom pipelines for your imaging data analysis. With Spring Science, everything you need is integrated and ready to go, making your research faster and more efficient. 🔍 Why Choose Spring? Seamless Integration: Our platform is designed to be an extension of your lab, eliminating the need for deep coding expertise. AI Embeddings for Superior Insights: Experience better accuracy and predictions with our state-of-the-art AI technology. Proven Capability: We've analyzed hundreds of terabytes of Cell Painting datasets, showcasing our platform's capability to handle extensive data workloads. Let's transform your research experience. Dive into the world of effortless data analysis with Spring Science! #SpringScience #CellPainting #AI #DataAnalysis #ScientificInnovation

At Spring Science, we're pioneering the future of drug discovery through AI-powered image analysis. Our specialized models are revolutionizing how we identify and develop potential treatments, aligning with the vision of accelerated progress in biology and health outlined by industry leaders like Dario Amodei of Anthropic. We're not just participants in this AI revolution - we're driving it forward. Our approach leverages smaller, specially trained AI models that excel at analyzing complex biological images. This targeted focus allows us to uncover insights and patterns that traditional methods might miss, potentially shaving years off the drug development timeline. Imagine a world where breakthrough treatments for cancer, Alzheimer's, and other devastating diseases are discovered in months rather than decades. This isn't science fiction - it's the future we're building at Spring Science. But we can't do it alone. We're calling on researchers, industry partners, and forward-thinking individuals to join us in this mission. Together, we can harness the power of AI to address global health challenges and usher in a new era of medical innovation. How do you envision AI transforming healthcare? Share your thoughts and let's start a conversation about the incredible possibilities ahead. Read more in our new blog post: https://xmrrwallet.com/cmx.pbuff.ly/4f8OgWx #AIinHealthcare #DrugDiscovery #FutureofMedicine