Axoft

We are thrilled to announce the successful completion of the first four cases in Axoft's first-in-human clinical study (FINESSE) using our ultrasoft Fleuron™ probes. Our new research preprint (link ⬇️) highlights major breakthroughs toward achieving stable, high-density, and clinically viable Brain-Computer Interfaces. This major step brings Axoft one step closer to helping millions of patients suffering from neurological disorders.   Key insights from our clinical and preclinical studies:   - In-human testing demonstrated Fleuron probes' ability to reliably capture high-density neural data from depth into the human brain (without observing signal drift or catastrophic failure modes that are common with laminar, high-density silicon probes) - Fleuron probes can detect neural correlates of depth of consciousness in response to auditory paradigms with high signal-to-noise ratio and temporal precision - Fleuron minimizes chronic glial encapsulation and implant micromotion compared to rigid polyimide used in current state-of-the-art neural interfaces - Fleuron probes achieve stable single-neuron resolution recordings for over 18 months in preclinical studies - Fleuron probes integrate seamlessly into minimally invasive surgical workflows and offer unique visibility in post-operative clinical MRI   Press release: https://xmrrwallet.com/cmx.plnkd.in/e_vsJRnH https://xmrrwallet.com/cmx.plnkd.in/ek6_n3Nz Preprint: https://xmrrwallet.com/cmx.plnkd.in/gP3KW9aR Clinical study: https://xmrrwallet.com/cmx.plnkd.in/eq7ZFQdS We are incredibly thankful to all the clinical study participants, Axoft team members, collaborators and supporters involved in this project! Jongha Lee Hyunsu Park Andrew Spencer Xian Gong Matt DeNardo Foad Vashahi Florent Pollet Sam Norris Henry Hinton Méliya El Fakiri Anant Mehrotra Rongchen Huang Julian Bär Jake Swann David Affonseca Jr. Oliver Armitage Ryan Garry Emily Grumbles Akash Murali Jordy TASSERIE Caua Fragoso Romain Albouy Charles Couturier Angelique Christine Paulk Brian Coughlin Sydney Cash Beth Costine-Bartell @Benjamin Baskin Tawny Stinson Homeira Moradi Chameh @Mandana Movahed @Bamdad Bazrgar @Darren Zhang Taufik Valiant @Ariel Francis @Carlos Candanedo Ricardo Bermudez Jia Liu Tianyang Ye Harvard John A. Paulson School of Engineering and Applied Sciences Harvard Medical School Mass General Brigham The Panama Clinic University Health Network bioaccess® LATAM MEDTECH CRO #Neurotechnology #BCI #Neuroscience #Innovation #FirstInHuman #Axoft

🚀 Axoft is expanding to Europe! We’ve just opened a subsidiary in Grenoble, France - a vibrant hub at the intersection of deeptech, medtech, and neuroscience. This marks an exciting step as we grow our clinical and commercial presence in Europe. Looking forward to new collaborations in the Alps and beyond 🇫🇷🧠 #Neurotech #Deeptech #BCI #Medtech #Grenoble #Axoft

It’s Magazine Monday! Today we’re focused on an LSI Alumni Innovator Spotlight featuring Axoft's Paul Le Floch. The Harvard University-trained materials scientist and Forbes 30 Under 30 honoree is reengineering how the brain and technology communicate, starting with a radically soft implant and a bold plan to decode the natural language of the brain. Subscribe to the newsletter for bi-monthly insights on the most important developments in Medtech, straight from The Lens Magazine, by LSI. Purchase a premium subscription to The Lens for monthly insights and thought leadership featuring top executives like Lisa Earnhardt, Gary Guthart, and Ray Cohen.

This week Axoft is presenting at Neural Interfaces 2025, hosted by the North American Neuromodulation Society (NANS), in Arlington, VA. Our late-breaking poster covers the results of our First-In-Human study using our Fleuron™ neural interface.   Come find Oliver Armitage in the Sky View room between 5 and 6pm today!

Today, we’re thrilled to share new research published in #Nature that introduces a novel brain implant application made possible with Axoft Materials. The research (link ⬇️) shows how Axoft’s ultra-soft Fleuron™ material can be used to overcome the long-standing challenge of designing bioelectronics capable of stably tracking neural activities in the developing brain as it undergoes large morphological changes. This work is an important milestone toward the development of future #biohybrids and brain-computer interfaces. A massive congrats and thank you to all of the authors of this impactful research! In particular, Hao Sheng, Ren Liu, Qiang Li, Zuwan Lin and Prof. Jia Liu, co-founder and scientific advisor at Axoft. Recording neural activity at the cellular level throughout brain development is critical in the study of neuroscience and neurodevelopmental disorders, however conventional rigid implants present fundamental mechanical mismatches between electronic and biological materials – making it impossible to interrogate the highly dynamic developing brain with accuracy, compatibility or longevity. This newly published research outlines how a Fleuron™-based, tissue-level-soft, sub-micrometer-thick, stretchable mesh microelectrode array can: - Leverage the 2D-to-3D reconfiguration process of brain tissue during embryonic development to stretch and distribute throughout the entire brain, fully integrating into the 3D tissue structure. - Show no discernible impact on brain development or function, as proven through immunostaining, gene expression analysis and behavioral testing. - Enable long-term, stable, brain-wide, single-unit-single-spike-resolved electrical mapping, and thereby illustrate how neural electrical activities and population dynamics emerge and evolve during brain development. The figure below shows: The seamless integration of the Fleuron-based mesh electronics inside a tadpole neural tube (left); Scanning Electron Microscopy of the Fleuron-based mesh electronics (right) Research paper: https://xmrrwallet.com/cmx.plnkd.in/eMAuiHtz More info on Axoft Materials: https://xmrrwallet.com/cmx.plnkd.in/eRNvvMc7 Harvard John A. Paulson School of Engineering and Applied Sciences Harvard Medical School Broad Institute of MIT and Harvard The University of Texas at Austin #neurotechnology #bci #biohybrids #cyborgs

We're thrilled to announce Oliver Armitage joining the leadership team at Axoft as Vice President of Neural Data and Clinical Strategy.   Oliver brings with him over ten years of Founder and Chief Scientific Officer experience from BIOS Health where he developed novel methods of using AI to analyze neural biomarkers and optimize neurostimulation settings. As a YCombinator alumni and Forbes 30 U 30, Oliver has contributed to several clinical neural interface development projects, bringing valuable expertise to Axoft. Prior to BIOS, he conducted his Ph.D. work at the University of Cambridge in soft tissue mechanics. At Axoft, Oliver focuses on the development of neural decoding with foundation models and its clinical applications. Welcome to the #team!

Axoft at the BCI Society meeting this week | Banff, Alberta (Canada) We’re thrilled to join the global neurotechnology community this week at the BCI Society Meeting; a hub of cutting-edge science, clinical innovation, and bold ideas in brain-computer interfaces. If you're attending, look for Matt DeNardo, VP of Product Development at Axoft, who is sharing insights from our First-in-human study and the multiple successful cases accomplished over the last few months using our ultrasoft neural interface. #Neurotechnology #BCI #Firstinhuman

Today we're excited to launch our first #product via Axoft Materials, the dedicated home of our groundbreaking #Fleuron™ materials. Axoft has also secured an exclusive license agreement with Stanford University to protect this innovative technology. Learn more about Fleuron™ here: https://xmrrwallet.com/cmx.plnkd.in/eRNvvMc7 Press release: https://xmrrwallet.com/cmx.plnkd.in/eD2uYJMB #Milestone #Innovation #Soft #Materials #Bioelectronics

Throwback to LSI USA in Dana Point this March - weeks before a major milestone at Axoft.   Since then, Axoft completed intraoperative testing of its #FDA #Breakthrough Brain-Computer Interface technology in four patients at The Panama Clinic.   🎥 Here’s a sneak peek from Paul Le Floch at #LSIUSA25, introducing Fleuron™ - Axoft’s proprietary ultrasoft neural interface platform designed to achieve stable, high-density, and clinically viable Brain-Computer Interfaces.   Our latest #medRxiv preprint highlights major breakthrough results that followed this presentation.   ▶️ Full video: https://xmrrwallet.com/cmx.plnkd.in/eKyaArq7 📄 Preprint: preprint.axoft.us   Huge thanks to LSI and everyone who joined us at #LSIUSA25!