A systematic review and meta-analysis to evaluate the efficacy of antipsychotic drugs in
subjects with cocaine dependence is presented. Twelve randomized, double-blind, placebo-
controlled clinical trials involving 681 patients were included. Five outcome measures were
evaluated: number of dropouts, cocaine use assessed by means of urine benzoylecgonine
tests, self-reported cocaine use, craving and Addiction Severity Index. On average, 48% of
the enrolled participants were lost to follow-up. In comparison to placebo, antipsychotics did …